If you absolutely must have everything unlocked immediately , buy the game on Steam (PC), use the console command unlock all , then use a save file transfer tool (like SyncThing) to move that save to your Android root directory. But that’s a $10 + 2 hours of work solution.
Mostly no, with dangerous exceptions.
There are 20 Ascension levels per character. You unlock Ascension 2 by beating Ascension 1, etc. This is the grindiest part. slay the spire android unlock everything work
How to transfer save data from Steam to Android : r/slaythespire If you absolutely must have everything unlocked immediately
Since Slay the Spire stores progress in plain-text preference files, you can manually unlock characters, cards, and relics by editing specific ID values. There are 20 Ascension levels per character
The simplest way to fix stuck unlocks or speed up the process without technical tools is to use a secondary profile. In the main menu, create a second save slot.