If your trackpad isn't working, install the ASUS Smart Gesture or Elantech/Synaptics driver. If it stops working after sleep, try switching the driver to the "HID-compliant touchpad" version in Device Manager. Graphics:
If driver repacks keep crashing your ASUS K53S, remember that or Ubuntu will run perfectly out-of-the-box on this hardware, with full driver support and better performance than Windows 10. Asus K53s Drivers Windows 10 64-bit REPACK