Rare has banned thousands of accounts for "unsporting behavior," including macro users. In high-profile cases (e.g., Twitch streamers using a Zen for double-gun), Rare has issued permanent hardware bans (banning the console's unique ID).
Before you scream "HACKER!" in open mic, know that Sea of Thieves has highly skilled players. However, Zen users leave specific fingerprints. sea of thieves cronus zen script