A Mab A Case Study In Bioprocess Development

Changed from top addition of Na₂CO₃ to a dip-pipe with an efficient mixing zone and implemented pH-stat control with CO₂ sparging . At 2,000L stainless steel bioreactor, aggregation dropped to 1.5%.

Fractogel EMD TMAE.

Even after Protein A, impurities remain. We implemented a two-step polishing phase: A Mab A Case Study In Bioprocess Development